Father O'Malley is sent to St. Mary's, a run-down parochial school on the verge of condemnation. He and Sister Benedict work together in an attempt to save the school, though their differing methods often lead to good-natured disagreements.

In 1942, a young paratrooper in the RAF returns to Czechoslovakia to encourage his fellow countrymen to sabotage the German war effort.

In this 13th entry to the Dr. Kildare series, the medical staff of Blair General hospital are challenged with further dilemmas, not the least of which includes a prison inmate who Dr. Gillespie believes belongs instead in an insane asylum.

With the army after him and his partner deserting, Reb decides that a change of scenery would be nice so he heads for Wyoming with Dave.