A Thai youth soccer team and their assistant coach are trapped within Tham Luang Cave, prompting a global rescue effort.

Flight attendant Cassandra Bowden wakes in her hotel room hungover from the night before in Dubai with a dead body lying next to her. Afraid to call the police, she continues her morning as if nothing happened. In New York, she is met by FBI agents who question her about her recent layover in Bangkok. Still unable to piece the night together, she begins to wonder if she could be the killer.

The 38-year-old bodybuilder Dennis would really like to find true love. He has never had a girlfriend and lives alone with his mother in a suburb of Copenhagen. When his uncle marries a girl from Thailand, Dennis decides to try his own luck on a trip to Pattaya, as it seems that love is easier to find in Thailand. He knows that his mother would never accept another woman in his life, so he lies and tells her that he is going to Germany. Dennis has never been out traveling before and the hectic Pattaya is a huge cultural shock for him. The intrusive Thai girls give big bruises to Dennis' naive picture of what love should be like, and he is about to lose hope when he unexpectedly meets the Thai woman Toi.

The Hangover crew heads to Thailand for Stu's wedding. After the disaster of a bachelor party in Las Vegas last year, Stu is playing it safe with a mellow pre-wedding brunch. However, nothing goes as planned and Bangkok is the perfect setting for another adventure with the rowdy group.