Highly intelligent computer major Zoey Miller is uninterested in romantic love, but her life is turned upside down when Zack, the school's soccer star, gets amnesia and mistakes Zoey for his girlfriend.

Two friends set out to make a movie that will change their lives, but they borrow money from the wrong guy. When they lose their star, and the production falls apart, they become aware that the situation is much graver than once thought. As their fates are decided, the audience realizes everything is not as it seems.

Mia, an aspiring actress, serves lattes to movie stars in between auditions and Sebastian, a jazz musician, scrapes by playing cocktail party gigs in dingy bars, but as success mounts they are faced with decisions that begin to fray the fragile fabric of their love affair, and the dreams they worked so hard to maintain in each other threaten to rip them apart.

Perhaps their strikingly different personalities make the relationship between detective Jane Rizzoli and medical examiner Maura Isles so effective. Jane, the only female cop in Boston's homicide division, is tough, relentless and rarely lets her guard down, while the impeccably dressed Maura displays a sometimes icy temperament — she is, after all, more comfortable among the dead than the living. Together, the best friends have forged a quirky and supportive relationship; they drop the protective shield in each other's company, and combine their expertise to solve Boston's most complex cases.