Charting the life of Isabella I of Castile, one of the most important women in Spain’s history, Isabel follows her passionate story from childhood to being crowned Queen. From her political struggles within King Henry IV's court to her wedding to Ferdinand of Aragon, the drama encapsulates the passions, emotions and sacrifices of a woman who refused to just be a figurehead and whose outlook was ahead of her time.

Recounts the experiences of a middle-class family, the Alcántaras, during the last years of the rule of Francisco Franco and the beginning of the Spanish Transition to democracy.