In the future, an outbreak of canine flu leads the mayor of a Japanese city to banish all dogs to an island used as a garbage dump. The outcasts must soon embark on an epic journey when a 12-year-old boy arrives on the island to find his beloved pet.

A fading actor best known for his portrayal of a popular superhero attempts to mount a comeback by appearing in a Broadway play. As opening night approaches, his attempts to become more altruistic, rebuild his career, and reconnect with friends and family prove more difficult than expected.