Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.

A man's brother dies of an overdose from a new and potent drug introduced by a drug gang. He puts off his wedding to a beautiful model and postpones taking over the family business while he travels to Hong Kong to learn Tiger Claw kung fu from its master. Then he plans to take his revenge on the drug dealers responsible for his brother's death.