Pakistan-born comedian Kumail Nanjiani and grad student Emily Gardner fall in love but struggle as their cultures clash. When Emily contracts a mysterious illness, Kumail finds himself forced to face her feisty parents, his family's expectations, and his true feelings.

A week in the life of Paterson, a poet bus driver, and his wife Laura, a very creative artist, who live in Paterson, New Jersey, hometown of many famous poets and artists.