On her wedding night, Jade wakes up holding the hand of her dead husband after she narrowly survived a murder attempt by the criminal family she fled from only weeks before. After pawning her wedding ring for a 357 Magnum she tries to kill a member of the family and botches the attempt. However, a Vietnam Veteran "The Hammer", comes to her aid and finishes the kill, saving her life. Over the next year, Hammer trains her to be a methodical assassin and on her wedding anniversary each member of the family will pay for their sins as she hunts them down with six bullets marked for revenge.

The Devil's daughter rises from the grave, bringing with her zombies, werewolves, vampires and the armies of Hell to destroy Earth. Mankind's only hope for salvation lies in a young hippie girl and a comic book geek.

John, Julian and Paul enter the Kaibab National Forest for a three-week survival trip and peyote vision quest. The only items they take with them are a knife, a bottle of water and a garbage bag each. A week into their journey a disastrous turn of events changes everything and the men are forced to ultimately confront the darkest corners of their morality and mortality. Battling the elements and each other, the quest becomes to make it out of the forest alive.