The Herlihys are a working class family from Chicago whose three children take wildly divergent paths: Brian joins the Marines right out of High School and goes to Vietnam, Michael becomes involved in the civil rights movement and after campaigning for Bobby Kennedy and Eugene McCarthy becomes involved in radical politics, and Katie gets pregnant, moves to San Francisco and joins a hippie commune. Meanwhile, the Taylors are an African-American family living in the deep South. When Willie Taylor, a minister and civil rights organizer, is shot to death, his son Emmet moves to the city and eventually joins the Black Panthers, serving as a bodyguard for Fred Hampton.

During his long career, bounty hunter Ralph "Papa" Thorson has caught over 5,000 criminals. Now, while he is working on apprehending fugitives in Illinois, Texas and Nebraska, he himself is being hunted by a psychotic killer.

Julian makes a lucrative living as an escort to older women in the Los Angeles area. He begins a relationship with Michelle, a local politician's wife, without expecting any pay. One of his clients is murdered and Detective Sunday begins pumping him for details on his different clients, something he is reluctant to do considering the nature of his work. Julian begins to suspect he's being framed. Meanwhile Michelle begins to fall in love with him.

A dedicated schoolteacher spends her nights cruising bars, looking for abusive men with whom she can engage in progressively violent sexual encounters.

During the 1972 elections, two reporters' investigation sheds light on the controversial Watergate scandal that compels President Nixon to resign from his post.