There's a deficit of good, honest women in the West, and Roy Whitman wants to change that. His solution is to bring a caravan of over 100 mail-order brides from Chicago to California. It will be a long, difficult and dangerous journey for the women. So Whitman hires hardened, cynical Buck Wyatt to be their guide across the inhospitable frontier. But as disaster strikes on the trail, Buck just might discover that these women are stronger than he thinks.

The title insurrection in this low-budget Whip Wilson Western consists mainly of Iron Eyes Cody, who is conspiring to raid the wagon trains with crooked sheriff Marshall Reed and nefarious Indian agent Forrest Taylor.

Texas Ranger Dusty Rivers ("Isn't that a contradiction in terms?", another character asks him) travels to Canada in the 1880s in search of Jacques Corbeau, who is wanted for murder. He wanders into the midst of the Riel Rebellion, in which Métis (people of French and Native heritage) and Natives want a separate nation. Dusty falls for nurse April Logan, who is also loved by Mountie Jim Brett. April's brother is involved with Courbeau's daughter Louvette, which leads to trouble during the battles between the rebels and the Mounties. Through it all Dusty is determined to bring Corbeau back to Texas (and April, too, if he can manage it.)

A group of pilots, because of unsavory or unearned reputations, establish an outpost squadron of their own, led by "Loop" Gillian, running charter-flights and hauling supplies in the frozen wastelands of Alaska. The operation does not go without misadventures, foul-ups, and a bit of treachery tossed in.