Cannibal Clown Killer is an 80's style post-apocalyptic landscape where half the earth's population has been killed off by a bacteria which contaminated gluten food filler and MSG products. Of those who did not die they awoke to a new nightmare, half the survivors had been turned into man-eating mad clowns hell-bent on consuming the world. In the dawn of this new world filled with blood, horrors, and painted faces a single female warrior has emerged. With a blade at her back, this nameless hero tracks across this wilderness saving those she can while on her quest for the clown that killed her parents. Happy Jack.

In the dead of night, Donovan drives with his girlfriend, Lucy and several friends to a secret rendezvous in the woods. They believe they are meeting a "healer" who can cure Lucy's cancer, but they grow suspicious when a booby-trap in the road forces them to stop short of their destination. when the driver gets out to investigate he is brutally killed and dragged from the car. Terrified, the remaining friends run for their lives to a deserted cabin, dodging the paramilitary commandos that hunt them as well as the deadly creatures that slaughtered their friends. As the friends die, one by one, they realize too late that Donovan has set them up as bait in exchange for a magic elixir he believes will heal Lucy, but even Donovan is not prepared to pay the price for Lucy's cure.