The starship Enterprise and its crew is pulled back into action when old nemesis, Khan, steals a top secret device called Project Genesis.

David and Carolyn marry in Hawaii and continue to work to find a cure for both their afflictions in a race against time.

During an experiment gone bad, radiation turns a scientist into a raging green behemoth whenever he becomes agitated. Unable to control his transformations, David Banner searches for a cure as he crosses the country, fugitive-style, with a dogged tabloid reporter on his trail.