Maggie's plan to have a baby on her own with a sperm donor is derailed when she falls in love with John, an older married professor, destroying his volatile marriage to the brilliant and impossible Georgette. But three years later, married to John with one daughter, Maggie is out of love and in a quandary: what do you do when you suspect your man and his ex-wife are actually perfect for each other?

Undiagnosed, untreated and generally untethered schizophrenic Julien lives with his pregnant younger sister Pearl, would-be wrestler brother Chris, sympathetic grandmother, and severely depressed German father.