Pennsylvania, 1956. Frank Sheeran, a war veteran of Irish origin who works as a truck driver, accidentally meets mobster Russell Bufalino. Once Frank becomes his trusted man, Bufalino sends him to Chicago with the task of helping Jimmy Hoffa, a powerful union leader related to organized crime, with whom Frank will maintain a close friendship for nearly twenty years.

Doctor Henry Morgan, New York City’s star medical examiner, has a secret. He doesn't just study the dead to solve criminal cases, he does it to solve the mystery that has eluded him for 200 years—the answer to his own inexplicable immortality. This long life has given Henry remarkable observation skills which impresses his new partner, Detective Jo Martinez. Each week, a new case and their budding friendship will reveal layers of Henry’s long and colorful past. Only his best friend and confidant, Abe knows Henry’s secret.

In the criminal justice system, sexually-based offenses are considered especially heinous. In New York City, the dedicated detectives who investigate these vicious felonies are members of an elite squad known as the Special Victims Unit. These are their stories.