Rachel is a divorced single mother whose bad day gets even worse. She's running late to drop her son off at school when she honks her horn impatiently at a fellow driver during rush-hour traffic. After an exchange of words, she soon realizes that the mysterious man is following her and her young son in his truck. A case of road rage quickly escalates, at horrifyingly psychotic proportions, into full-blown terror as Rachel discovers the psychopath's sinister plan for revenge. He is single-mindedly determined to teach her a deadly lesson.

Dispatched from his basement room on an errand for his mother, slacker Jeff might discover his destiny (finally) when he spends the day with his brother as he tracks his possibly adulterous wife.

Terrence McDonagh is a New Orleans Police sergeant, who recieves a medal and a promotion to lieutenant for heroism during Hurricane Katrina. Due to his heroic act, McDonagh injures his back and becomes addicted to prescription pain medication. He then finds himself involved with a drug dealer who is suspected of murdering a family of African immigrants.