Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.

Sarah Silverman appears before an audience in Los Angeles with several sketches, taped outside the theater, intercut into the stand-up performance. Themes include race, sex, and religion. Her comic persona is a self-centered hipster, brash and clueless about her political incorrectness. A handful of musical numbers punctuate the performance.

A group of kids on a field trip shockingly discover the bodies of missing children. Their alarming discovery leads to a small western town where the mystery of the slain children's disappearance has created an environment of suspicion and distrust. A curious reporter from the city arrives in town and bribes a bar owner to divulge everything she knows. Gradually, the pieces of this disturbing puzzle; deception, adultery and secret bonds, start falling into place. They hold the key to the mystery of the murdered children.

A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.

Pulled to the far side of the galaxy, where the Federation is 75 years away at maximum warp speed, a Starfleet ship must cooperate with Maquis rebels to find a way home.