Movie star Vincent Chase, together with his boys, Eric, Turtle and Johnny, are back…and back in business with super agent-turned-studio head Ari Gold. Some of their ambitions have changed, but the bond between them remains strong as they navigate the capricious and often cutthroat world of Hollywood.

While investigating the disappearance of an US Marine recruit at a top secret SERE (Survival, Evasion, Resistance & Escape) training site, Avril Heart, an undercover Department of Homeland Security agent, endures 'enhanced interrogation' in order to learn the truth. After the death of another Marine cooperating with her investigation, Agent Heart discovers a shocking conspiracy that calls into question everything she is fighting for.