In 1970, Mikey and William both portrayed football cannibal Smash-Mouth in the influential cult hit, End Zone 2. Now, 50 years later, only one can wear the mask.

Mean and domineering Jane and the sweet and ditsy Jackie are two radically contrasting sisters who suffer from severe trauma after witnessing the murder/suicide of their parents as well as seeing their other sibling Janice raped and killed by her assailants. The pair are deemed fit to re-enter society and get released from a sanitarium where they have undergone extensive rehabilitation therapy. However, Jane and Jackie prove to be anything but sane and harmless as they embark on a vicious spree in which they torture, murder, and mutilate any man luckless enough to cross their lethal paths.

A team of teenagers with attitude are recruited to save Angel Grove from the evil witch, Rita Repulsa, and later, Lord Zedd, Emperor of all he sees, and their horde of monsters.