Follows a seasoned detective on the trail of a ruthless killer intent on slaughtering prostitutes along West Hollywood's Sunset Strip. It appears that the murderer's grisly methods are identical to that of London's infamous 19th century psychopath Jack the Ripper – a relentless serial killer who was never caught by police. To make matters worse, the detective soon notices the parallels between the crimes committed by the West Hollywood stalker and those of a serial murderer incarcerated years ago. Could the wrong man be behind bars?

Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.