A university graduate working in the city morgue is able to repeat the same day over again to prevent murders or other disasters.

When calls to her grandmother go unanswered, Jamie Lowell uncovers the truth behind her mysterious disappearance.

"There are those among us who can move at will between the world of the wolves and the world of the humans. My people call them skin walkers." Seattle police detective John Kanin has a problem. He's in love, but shortly after agreeing to marry him, his girlfriend disapears. His search leads to her home town, where people are clearly hiding information from him. One of the things they are hiding is the fact that they are all werewolves, as is John's girlfriend, Ruby.

Detectives Nick O'Malley and Kate Benson work in Special Unit 2, a secret precinct of the Chicago Police Department whose sole charge is to protect the city's citizens from Links, a malicious paranormal species that is the missing link between man and beast.