Ben and Katie Jordan are a married couple who go through hard times in fifteen years of marriage.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.

Just after a bad breakup, Charlie MacKenzie falls for lovely butcher Harriet Michaels and introduces her to his parents. But, as voracious consumers of sensational tabloids, his parents soon come to suspect that Harriet is actually a notorious serial killer -- "Mrs. X" -- wanted in connection with a string of bizarre honeymoon killings. Thinking his parents foolish, Charlie proposes to Harriet. But while on his honeymoon with her, he begins to fear they were right.

Larry McAfee is paralyzed from the neck down following a motorcycle accident. He gradually loses the will to live, in the meantime befriending a talk radio DJ over the phone. The two meet each other and become friends, though Larry still wishes to end his life. The DJ reluctantly has a switch installed on Larry's life support that Larry can activate at any time (via his mouth) to end his life.