A television program is interupted by a news network announcing that three meteors have hit the United States, France and China. At first it seems natural but after interviews by scientists and eyewitness seems to suggest that it is not. Three more meteors are coming and the various Earth governments combine forces to stop them.

Dr. Mark Sloan is a good-natured, offbeat physician who is called upon to solve murders.

The Newton family live in their comfortable home, but there seems to something missing. This "hole" is filled by a small puppy, who walks into their home and their lives. Beethoven, as he is named, grows into a giant of a dog... a St Bernard. Doctor Varnick, the local vet has a secret and horrible sideline, which requires lots of dogs for experiments. Beethoven is on the bad doctor's list.

A male prison escapee heads for his hidden loot, electronically attached to a female prisoner.