When the president of Russia suddenly dies, a man whose politics are virtually unknown succeeds him. The change in political leaders sparks paranoia among American CIA officials, so CIA director Bill Cabot recruits a young analyst to supply insight and advice on the situation. Then the unthinkable happens: a nuclear bomb explodes in a U.S. city, and America is quick to blame the Russians.

In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.

Sent to Paris to visit their grandfather, the twins fall in love with France, not to mention two French boys.

In an alternate futuristic society, a tough female police detective is paired with a talking dinosaur to find the killer of dinosaurs and other prehistoric animals leading them to a mad scientist bent on creating a new Armageddon.

The story of the discovery of the AIDS epidemic and the political infighting of the scientific community hampering the early fight with it.

Brothers Brian and Joe Hackett attempt to run an airline on the New England island of Nantucket while surrounded by their various wacky friends and employees.