Mysterious experiments are going on at the Biogen 4 Research Labs. And now, those experiments...are loose! Monsters...creatures...hungry for flesh and blood.

MANOS Returns is the follow up film to the cult favorite Manos: The Hands of Fate, created by Jackey Neyman Jones who portrayed Debbie from the original film.

The small Oregon town of Oak Creek was shaken to the core when logger Bud Kindrick lost his mind and went on a killing spree after discovering a terrible secret. Now, nearly a year later, the killings have begun again and echo those committed by Kindrick, who had been dubbed the Blood Creek Woodsman. The town Sheriff, his estranged wife, his deputy and a pushy reporter must get to the bottom of what's going on while the bodies pile up around them.

After losing their jobs, two estranged brothers find themselves in a love triangle. Constantly looked up to as a hero, Stone Lewis struggles to save the one person he truly loves: his brother.