When a hapless, unfunny, wanna-be comedian picks up a mysterious hitchhiker on his way to Vegas to audition for the Monte Guy show, he unwittingly becomes trapped in a desert-town killing spree that also has a very unexpected consequence - it improves his comedy.

Determined to find out the true effects of marijuana on the human body, stand-up comedian and former Stoner of the Year Doug Benson documents his experience avoiding pot for 30 days and then consuming massive amounts of the drug for 30 days. More than just an amusing story of one man's quest to get superhigh, this documentary also examines the hotly contested debate over medical marijuana use.