John "Breacher" Wharton leads an elite DEA task force that takes on the world's deadliest drug cartels. When the team successfully executes a high-stakes raid on a cartel safe house, they think their work is done – until, one-by-one, the team members mysteriously start to be eliminated. As the body count rises, everyone is a suspect.

In a temper, Meg, a cynical, overworked TV executive, rants about how the movies she produces lie, making you think dreams can come true, and tries to smash her favorite snow globe. Instead, it hits her on the head and knocks her out. When she comes to, she finds herself magically transported to a perfect snow-covered town like the one in her globe, married to a handsome woodworker and mother to two young children.

In the gritty world of the NYPD, no one's tougher than Detective Robert Ironside. He and his trusted, handpicked team of specialists will do whatever it takes to solve New York's most difficult and notorious crimes - even if it means breaking the rules. As a detective, his instincts are second to none, and those around him have to stay on their toes if they want to keep up...because when his spine was shattered by a bullet two years ago, Ironside swore he'd never let a damn wheelchair slow him down.

Chicagoan Frank Gallagher is the proud single dad of six smart, industrious, independent kids, who without him would be... perhaps better off. When Frank's not at the bar spending what little money they have, he's passed out on the floor. But the kids have found ways to grow up in spite of him. They may not be like any family you know, but they make no apologies for being exactly who they are.

Perhaps their strikingly different personalities make the relationship between detective Jane Rizzoli and medical examiner Maura Isles so effective. Jane, the only female cop in Boston's homicide division, is tough, relentless and rarely lets her guard down, while the impeccably dressed Maura displays a sometimes icy temperament — she is, after all, more comfortable among the dead than the living. Together, the best friends have forged a quirky and supportive relationship; they drop the protective shield in each other's company, and combine their expertise to solve Boston's most complex cases.

Alejandro, a tough and ambitious Latino street orphan on the verge of adolescence, lives and works in an auto-body repair shop in a sprawling junkyard on the outskirts of Queens, New York. In this chaotic world of adults, young Alejandro struggles to make a better life for himself and his 16-year-old sister, Isamar.