Part live-action, part animated story about a boy who, after an awful amusement park accident, gets a brain transplant, which allows him to see cartoon characters in real life.

Newlywed Melinda Gordon tries to help the dead communicate with loved ones, but sometimes the messages she receives are intense and confusing. Most of Melinda's efforts involve resolving conflicts that are preventing the spirits from passing over.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

The series follows the ventures of a Missing Persons Unit of the FBI in New York City.