A whiskey-fueled writing assignment takes one man on an epic motorcycle road trip through the bars and taverns across the American West. Riding a 1960 BMW R60/2, the journey leads Sanders from the red rock deserts of Arizona and Utah north to the mountains of Montana. With help of fellow traveler and sage, Northway and a variety of other colorful characters along the way, Sanders gets learns the way of the road and the zen of the bar.

Seven years after the events of the first film, Samantha Darko finds herself stranded in a small desert town after her car breaks down where she is plagued by bizarre visions telling of the universe's end. As a result, she must face her own demons, and in doing so, save the world and herself.