When Ethan arrives at the airport just in time to declare his undying love for his girlfriend, love appears to have conquered all. The scene, however, is really the ending of Ethan's novel, which his agent calls "unrealistic." Ethan soon meets a waitress, Jesse, and falls in love with her despite her growing devotion to Troy, a charming businessman. But the line between reality and fiction becomes increasingly blurred.

Seven years after the events of the first film, Samantha Darko finds herself stranded in a small desert town after her car breaks down where she is plagued by bizarre visions telling of the universe's end. As a result, she must face her own demons, and in doing so, save the world and herself.