Geoffrey is desperately in love with Mavis, who lives at his boardinghouse and is also pursuing a writing career. Unable to marry her because of his poverty, in his anger he curses God for abandoning him. Soon Geoffrey meets Prince Lucio de Rimanez, a wealthy, urbane gentleman who informs Geoffrey that he has inherited a fortune, but that he must place himself in the Prince's hands in order to enjoy the fruits of his inheritance. What Geoffrey doesn't know is that Prince Lucio is actually Satan.

Lovers in Quarantine is an extant 1925 silent film comedy starring Bebe Daniels and directed by Frank Tuttle. It was produced by Famous Players-Lasky and distributed by Paramount Pictures. the film is based on a 1924 Broadway play Quarantine by F. Tennyson Jesse. It is preserved at the Library of Congress.

Based on a Frederick Lonsdale Broadway play.