After getting dumped for the 11th time in a row, Frankie discovers that she has a "loser in love" gene, which predisposes her to chronic failure and rejection for the rest of her life. She decides to embark on a quest to change her romantic future.

New York, 1896. Police commissioner Theodore Roosevelt brings together criminal psychologist Dr. Laszlo Kreizler, newspaper illustrator John Moore and secretary Sara Howard to investigate several murders of male prostitutes.

A boy imagines a monster that helps him deal with his difficult life and see the world in a different way.