When her brother disappears during a brief travel layover in Mexico, Mitch begins a desperate search that will eventually lead the young divorcee into the capital city's most notorious neighborhood. But even with the aid of the American Ambassador, her plight is only met with indifference and inaction from the authorities. As the story unfolds, Mitch is forced to look for help in the least likely places as she races against time in a dangerous quest to find answers and locate her brother.

Workaholic Mike Flaherty is the Deputy Mayor of New York City, serving as Mayor Randall Winston's key strategist and much-needed handler. Mike runs the city with the help of his oddball staff: an anxious and insecure press secretary; a sexist, boorish chief of staff; an impeccably groomed gay activist running minority affairs; a sharp and efficient, man-crazy accountant; and an idealistic young speechwriter. Like Mike, they are all professionally capable but personally challenged.