Estranged fraternal twins Allen and Allie Foster are reunited by their mother's death, and return to their strange hometown of Obelisk Bay to attend to her lingering matters. Allen, struggling to resolve his latest novel, is enticed by Allie to take a powerful psychotropic drug she calls "the lotus." As if a muse were speaking through him, Allen begins recounting the winding story of a young woman's travels decades earlier. Her life in some ways parallels their own, as she journeys into the desert in search of a statue her own deceased mother left her with an old photograph of. The two lives begin to cross over in unexpected ways, and it becomes apparent that a dark secret at the heart of their old home has far broader ramifications than they could have possibly imagined.

On Halloween, an all girl rock-n-roll band called “Kill Pussy Kill” ventures out to play their biggest show to date. However, before hitting the road they manage to unwittingly upset a man. Unfortunately, this man turns out to be an evil genius dead set on revenge. The evil genius manages to lure the girls into his Hell House and when they wake up from being gassed, they find themselves trapped inside an inescapable room filled with a vicious variety of devices that can kill them as well as a variety of weapons that can be used on each other. The rules are simple: advance through all three rooms and you are allowed to go free. The catch is, in order to make it to the next room, someone must die!

Russel Brody, a one-time successful playwright, works diligently on a follow-up play that could land him back in the spotlight he so early craves. With a baby on the way, however, and a strained marriage, stress and frustration take center stage. When his wife accidentally stumbles down the stairs and dies from her injuries, Brody's mental state goes from bad to one of utter despair. In a bid to help his friend regain his sanity, Brody's co-writer David Stanley suggests he revisits Lucy, his former mistress. The ghost of Brody's dead wife awakens to the sordid details of his unfaithfulness, enraging her supernatural spirit to haunt him in every horrifying way imaginable.