A space shuttle crashes containing a lethal prototype organism designed to survive in any environment. The only people who can stop the creature are the Secretary of Defense agent and the female scientist who created it.

A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.

Six years ago, the space alien ALF was on his way back to his new home when the Alien Task Force finally caught up with him. Now he is being studied at a top-secret base. There he finds allies who feel that ALF's existence should be announced to the world to ensure his safety... especially when they learn that the abrasive Colonel Milfoil wants ALF destroyed.