Blind Pete Horne knows the location of the Lost Spanish Silver Lode, but is knifed before he can tell anyone. His seeing eye dog, Duke, brings Rex Allen and Gabriel Horne to Pete's lifeless body. They set out to find the killer and run into trouble near Silver City, Arizona, when they rescue Katie McIntosh from a gang that is chasing her buckboard.

Charles Starrett, aka "The Durango Kid", is back in Raiders of Tomahawk Creek. Starrett plays Steve Blake, a novice Indian agent, sent out to investigate a series of mysterious murders.

Joe Hanson, who believes himself to be tolerant of other races and religions, gradually comes to realize that he is prejudiced against many of them.

Little Larry Havens, whose father died in WWII, runs away from home to keep from being separated from "Shep," his father's dog. In Arizona, he is befriended by a kindly Mexican, Manuel Ortiz, who he is able to repay in time, with the aid of Sheriff "Cap" Weatherby, when Ortiz is suspected of crimes committed by local gangsters. "Shep" is instrumental in saving Ortiz from a lynching, and Larry, "Shep" and Ortiz all find a home with a couple they have befriended.

An ex-gunfighter woos two women while avenging his brother, victim of a crooked gambler.