After a comet disrupts the rain cycle of Earth, the planet has become a desolate, barren desert by the year 2033. With resources scarce, Kesslee — head of the powerful and evil Water & Power Corporation, the de facto government — has taken control of the water supply. Unwilling to cower under Kesslee's tyrannical rule, a pair of outlaws known as Tank Girl and Jet Girl rise up, joining the mysterious rebel Rippers to destroy the corrupt system.

An airline pilot and his wife are forced to face the consequences of her alcoholism when her addictions threaten her life and their daughter's safety. While the woman enters detox, her husband must face the truth of his enabling behavior.