After a comet disrupts the rain cycle of Earth, the planet has become a desolate, barren desert by the year 2033. With resources scarce, Kesslee — head of the powerful and evil Water & Power Corporation, the de facto government — has taken control of the water supply. Unwilling to cower under Kesslee's tyrannical rule, a pair of outlaws known as Tank Girl and Jet Girl rise up, joining the mysterious rebel Rippers to destroy the corrupt system.

The story of the greatest Native American warrior who, together with the rest of his Apache tribesmen, defied American and Mexican Armies in 1867. Finally caught and sent to a reservation camp, he eluded a military force of 5000 for 18 months before finally surrendering to the government.

A Vietnam veteran who has become a drifter helps a young, single mother avenge her brother's murder and finds himself the target of a gang of dope smugglers on the Mexican border.