After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!

Legendary undercover DEA agent Charlie Mayough has suddenly lost his nerves of steel. On the verge of a career-induced mental breakdown, and in complete fear of trigger-happy Mafia leader Fulvio Nesstra, Charlie seeks psychiatric help and finds himself relying on the support of an unstable therapy group and nurse Judy just to get through his work.

Hotel manager Robert Grant is forced by his boss to postpone his family vacation when a hotel critic checks in. Trouble is, the critic is really a villainous jewel thief with an orangutan assistant named Dunston. When Dunston gets loose and tries to escape a life of crime -- aided by Robert's sons -- havoc, hijinks and lots of laughs abound!