After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!

Russ Richards is a TV weatherman and local celebrity on the verge of losing his shirt. Desperate to escape financial ruin, he schemes with Crystal the TV station's lotto ball girl to rig the state lottery drawing. The numbers come up right, but everything else goes wrong as the plan starts to unravel and the game turns rough.

A preacher without resources spends his days reciting Bible verses. One day he meets a young jobless girl who wanders on Hollywood Boulevard. An impossible love story begins.

A team of teenagers with attitude are recruited to save Angel Grove from the evil witch, Rita Repulsa, and later, Lord Zedd, Emperor of all he sees, and their horde of monsters.