After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!

Two centuries in the future, when pollution has forced humans to abandon Earth in favor of cramped space stations, scientist Devon Adair hijacks a spacecraft and sets out with a band of followers in search of another planet that will offer a brighter, more normal future to children like her son, Ulysses. Joining Devon and Ulysses are mechanic John Danziger and his daughter, True; team physician Julia Heller, who has her own secret agenda; Alonzo Solace, a pilot; Yale, a cyborg; and Morgan, a craven government agent, and his wife, Bess. The voyagers find their planet, but their ship crash-lands on the wrong side of the globe, forcing them to attempt an arduous and dangerous trek to their ultimate destination, New Pacifica.