In the hip Brooklyn neighborhood of Red Hook, single dad and record store owner Frank is preparing to send his hard-working daughter Sam off to college while being forced to close his vintage shop. Hoping to stay connected through their shared musical passions, Frank urges Sam to turn their weekly jam sessions into a father-daughter live act. After their first song becomes an internet breakout, the two embark on a journey of love, growing up and musical discovery.

After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!