In a world mostly wiped out by the plague and embroiled in an elemental struggle between good and evil, the fate of mankind rests on the frail shoulders of the 108-year-old Mother Abagail and a handful of survivors. Their worst nightmares are embodied in a man with a lethal smile and unspeakable powers: Randall Flagg, the Dark Man.

One year after the events of "Kickboxer: Vengeance", Kurt Sloan has vowed never to return to Thailand. However, while gearing up for a MMA title shot, he finds himself sedated and forced back into Thailand, this time in prison. He is there because the ones responsible want him to face a 6'8" 400 lbs. beast named Mongkut and in return for the fight, Kurt will get two million dollars and his freedom back. Kurt at first refuses, in which a bounty is placed on his head as a way to force him to face Mongkut. Kurt soon learns he will have no other choice and will undergo his most rigorous training yet under some unexpected mentors in order to face Mongkut in hopes to regain his freedom.

The most dangerous former operative of the CIA is drawn out of hiding to uncover hidden truths about his past.