An embattled NYPD detective, is thrust into a citywide manhunt for a pair of cop killers after uncovering a massive and unexpected conspiracy. As the night unfolds, lines become blurred on who he is pursuing, and who is in pursuit of him.

The new medical director breaks the rules to heal the system at America's oldest public hospital. Max Goodwin sets out to tear up the bureaucracy and provide exceptional care, but the doctors and staff are not so sure he can succeed. They've heard this before. Not taking "no" for an answer, Dr. Goodwin's instinctive response to problems large and small is four simple words: "How can I help?" He has to disrupt the status quo and prove he'll stop at nothing to breathe new life into this underfunded and underappreciated hospital, returning it to the glory that put it on the map.

The most dangerous former operative of the CIA is drawn out of hiding to uncover hidden truths about his past.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.