Eight complete strangers are tested like never before when they wake up locked inside a mysterious house. With no memory of how or why they are there paranoia takes over, forcing them to make their own decisions on who to trust and how best to escape.

The film centers on Dr. Marcus, a renowned psychiatrist who has selected 6 severe mentally ill and dangerous patients from the Spring Valley Mental Hospital to interview as part of research for his new book. As Dr. Marcus interviews each patient, one by one the horrors they have committed begin to unfold. However, Dr. Marcus soon learns that there is one patient who ties them all together - Patient Seven.