Arrogant, self-centered movie director Guido Contini finds himself struggling to find meaning, purpose, and a script for his latest film endeavor. With only a week left before shooting begins, he desperately searches for answers and inspiration from his wife, his mistress, his muse, and his mother.

Giada is a overachieving student who works to pay for college. Riccardo is a spoiled brat who answers her tutoring ad in order to improve his abysmal grades. She's shy and homely. He's handsome and brazen. As they say, opposites attract.

Nicola, paralyzed after a car crash, falls in love for his physiotherapist Lucia. Franco and Manuela, a young couple unfit to have children, fly to Barcelona for a specialized treatment for fertility. Filippo and Fosco, two gay men, decide to marry. Ernesto, waiter in a chic restaurant, has a liaison with Cecilia, the new Spanish help.

Four intertwined stories on the joys and sorrows of love.