An award-winning cynical journalist, Lloyd Vogel, begrudgingly accepts an assignment to write an Esquire profile piece on the beloved television icon Fred Rogers. After his encounter with Rogers, Vogel's perspective on life is transformed.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

Rand is a computer animator, who has created an artificial intelligence creature designed to interact with children and teach them responsibility. When his prototype is forced into practice at a school, Rand encounters Sarah, a teacher he was inexplicably drawn to, at his favorite bar one fateful evening. Sparks fly between them, but fundamental differences in their approaches to love and relationships slow them down to a halt.