Respected liberal Senator Joe Tynan is asked to to lead the opposition to a Supreme Court appointment. It means losing an old friend and fudging principles to make the necessary deals, as well as further straining his already part-time family life. But it could be a big boost to his career, so he takes it on. Helping him prepare the case is pretty southern researcher Karen Traynor, and their developing relationship further complicates and compromises his life.

Frank Serpico is an idealistic New York City cop who refuses to take bribes, unlike the rest of the force. His actions get Frank shunned by the other officers, and often placed in dangerous situations by his partners. When his superiors ignore Frank's accusations of corruption, he decides to go public with the allegations. Although this causes the Knapp Commission to investigate his claims, Frank has also placed a target on himself.