A burned-out New York police detective teams up with a college psychoanalyst to track down a vicious serial killer randomly stalking and killing various young women around the city.

Frank Serpico is an idealistic New York City cop who refuses to take bribes, unlike the rest of the force. His actions get Frank shunned by the other officers, and often placed in dangerous situations by his partners. When his superiors ignore Frank's accusations of corruption, he decides to go public with the allegations. Although this causes the Knapp Commission to investigate his claims, Frank has also placed a target on himself.