Four door-to-door salesmen struggle to get by while pursuing an analog profession in a digital world. They unwittingly begin selling propaganda for a cult, whose popularity sweeps the city, leaving the salesmen as the only people who can stop it.

Aging local standup comic Sweeney, "The Character King", gets an opportunity to do a national cable show out of Los Angeles. The only caveat is that Sweeney must drop the locally referenced material from his act, the biggest pieces being the portrayal of his colorful Boston "characters," that have become a staple of his home field success. Sweeney makes the hard decision to stop doing the characters. But, to his dismay, the characters "come-to-life" and seek their revenge; they try to kill Sweeney.

Following a ghost invasion of Manhattan, paranormal enthusiasts Erin Gilbert and Abby Yates, nuclear engineer Jillian Holtzmann, and subway worker Patty Tolan band together to stop the otherworldly threat.