Barry Munday, a libido-driven wage slave who spends all his time either ogling, fantasizing about or trying to pick up women, wakes up in hospital after a freak attack only to find that his testicles have been removed.

Medical student Ted Grey graduates at the top of his class and quickly joins an elite pathology program, whose top students invite him into their circle. There he uncovers a gruesome secret: They play a game in which one tries to commit the perfect, undetectable murder, then the others compete to determine the victim's cause of death.